RISPERIDONE AND OLANZAPNE IN-PATIENT UTILIZATION IN THE UNIVERSITY OF MALAYA MEDICAL CENTRE, KUALA LUMPUR
The objective of this study was to compare in-patient drug use patterns,
costs, and outcomes associated with risperidone or olanzapine in a naturalistic clinical setting. Retrospective chart reviews of 92 patients with psychotic disorders were conducted at the University of Malaya Medical Centre (UMMC). Data was collected from patients who were hospitalized and for whom risperidone or olanzapine was the drug of first choice for long-term pharmacologic treatment. Proportion of patients for whom efficacy of the studied treatment could be established
(as rated by the treating physician) was higher, but not significantly, with risperidone compared to olanzapine (p = 0.46). The average dose of the studied medication was 2.9 ' 1.0 mg/day for risperidone and 9.7 ' 2.4 mg/day for olanzapine. The total cost was significantly higher (p < 0.0001) for olanzapine (RM140.40; 95% CI: 108.4'181.9) compared to risperidone (RM50.80, 95% CI: 39.5'65.3). The daily cost was also significantly higher for olanzapine (RM19.16; 95% CI: 17.72'20.72) compared to risperidone (RM4.95; 95% CI: 4.46'5.51, p < 0.0001). Analysis of responders showed significantly higher daily and total costs of treatment with olanzapine compared to risperidone. These preliminary data suggest that treatment with risperidone may be more costeffective than treatment with olanzapine. However, a longer duration of study and more data is needed before a proper conclusion on cost-effectiveness is made.
All authors agree that the article, if editorially accepted for publication, shall be licensed under the Creative Commons Attribution License 4.0 to allow others to freely access, copy and use research provided the author is correctly attributed, unless otherwise stated. All articles are available online without charge or other barriers to access. However, anyone wishing to reproduce large quantities of an article (250+) should inform the publisher. Any opinion expressed in the articles are those of the authors and do not reflect that of the University of Malaya, 50603 Kuala Lumpur, Malaysia.