THE ANTIOXIDANT MECHANISM IN THE PREVENTION OF TYPE 2 DIABETES AND ITS COMPLICATIONS: A NARRATIVE REVIEW

Received 2023-07-07; Accepted 2023-09-22; Published 2023-09-22

Authors

  • Mahmudur Rahman AHM Department of Basic Sciences, Faculty of Health Sciences, Universiti Teknologi MARA, Puncak Alam Campus, 42300 Puncak Alam, Selangor, Malaysia.
  • Farrah Shafeera Ibrahim Department of Basic Sciences, Faculty of Health Sciences, Universiti Teknologi MARA, Puncak Alam Campus, 42300 Puncak Alam, Selangor, Malaysia.
  • Zulkhairi Amom Department of Basic Sciences, Faculty of Health Sciences, Universiti Teknologi MARA, Puncak Alam Campus, 42300 Puncak Alam, Selangor, Malaysia.
  • Adel A. Amran Department of Physiology, Faculty of Medicine, Thamar University, Dhamar, Yemen.

DOI:

https://doi.org/10.22452/jummec.sp2023no2.45

Abstract

Type 2 diabetes mellitus (T2DM) is considered a chronic metabolic disease in which oxidative stress plays a vital part in the pathogenesis of diabetes. Essentially, hyperglycemia instigates the auto-oxidation of glucose to free radicals. The free radicals overwhelm endogenous antioxidant defense in macrovascular and microvascular dysfunctions. The antioxidants (such as vitamin C and α-lipoic acid) effectively reduce diabetic complications; they are used to treat and decrease the complication of diabetes mellitus. Supplementations with antioxidants and medicinal plants that possess antioxidant activity have been investigated for hypoglycemic effects. This review article sums up the role and mechanism of antioxidants in the prevention of T2DM and its complications.

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Author Biographies

Mahmudur Rahman AHM, Department of Basic Sciences, Faculty of Health Sciences, Universiti Teknologi MARA, Puncak Alam Campus, 42300 Puncak Alam, Selangor, Malaysia.

 

 

Zulkhairi Amom, Department of Basic Sciences, Faculty of Health Sciences, Universiti Teknologi MARA, Puncak Alam Campus, 42300 Puncak Alam, Selangor, Malaysia.

 

 

Adel A. Amran, Department of Physiology, Faculty of Medicine, Thamar University, Dhamar, Yemen.

 

 

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Published

2023-09-22

Issue

Special Issue 2 (2023): Postgraduate Research Colloquium

Section

Research article

License

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