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Fluoxetine is a common selective serotonin reuptake inhibitor (SSRI) used as a pharmacological neuromodulationagent for post-stroke motor recovery and treatment for post-stroke mood disorder. Although some SSRIs are known to cause bilateral symmetrical peripheral oedema, to datethere are no reported cases of oedemacaused by fluoxetine or reported cases of a unilateral peripheral oedema. We report a case of fluoxetine-induced unilateral facial and limb oedema in a patient with haemorrhagic stroke. The peripheral oedema was noted on the hemiparetic side within 48 hours after theinitiation of fluoxetine.The medication was then tapered off over two weeks, which resulted in gradual resolution of the oedema.
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