A RARE CASE OF MALIGNANT GIANT CELL TUMOR OF THE HYOID BONE TREATED WITH DENOSUMAB

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Nur Shezwani Akmal Nohd Sharif
Nur Asma Sapiai, Dr
Chandran Nadarajan, Dr

Abstract

Giant cell tumor of the bone (GCTB) is a benign bone tumor where it typically presents in the long bones, mainly at the knee regions. Rarely, benign GCTB can undergo sarcomatous malignant transformation (MGCTB). We report a case of a 63-year-old lady who presented with a swelling at the right side of the neck associated with dysphagia and voice changes. A contrast-enhanced computed tomography scan revealed a large mass seen arising from the hyoid bone with local mass effect and airway compression. However, no distant metastasis was seen. Multiple biopsies performed on the patient with the histopathology reports concluded as MGCTB. The tumor was unresectable. Therefore, the patient was treated with denosumab. She showed encouraging improvement post-treatment. We are highlighting this case report in view of the rare site of the disease and the use of denosumab in unresectable tumor with good response to therapy.

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Research article
Author Biographies

Nur Asma Sapiai, Dr, Department of Radiology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia

Lecturer/Radiologist,

Department of Radiology,

School Of Medical Sciences/USM Hospital,

Universiti Sains Malaysia, Health campus,

16150 Kota Bharu, Kelantan, Malaysia.

Phone : +609 767 6733

Fax : +609 767 3468

Chandran Nadarajan, Dr, Department of Radiology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia

Senior lecturer / Clinical and Interventional Radiologist,

School of Medical Sciences,

Hospital Universiti Sains Malaysia,

Health Campus, Universiti Sains Malaysia

16150 Kubang Kerian, Kelantan

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