COMPARISON OF PATHOGENESIS OF P. BERGHEI INFECTION IN MOUSE AND RAT MODELS

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Voon Kin Chin Wing Chui Chong Norshariza Nordin Tze Yan Lee Zakaria Zainul Amiruddin Haniza Hassan Rusliza Basir

Abstract

Background: The cytokine cascade in the immunopathogenesis of malaria infection had been widely studied. However, their specific association with survival and severe infection remained obscure. Methods: The study investigated the cytokine profiles and histopathological features of malaria in the severe infection and survival models by using male ICR mice and male Sprague Dawley rats respectively. Results: The severe model, the infected ICR mice, exhibited a high parasitemia with 100% mortality after peak parasitemia at day 5 post-infection. The survival model, the infected Sprague Dawley rats, showed mild parasitemia with full recovery by day 14 of infection. Both severe and survival models showed similar histopathological severity during peak parasitemia. The severe model produced highly elevated levels of proinflammatory cytokines, TNF-α and IL-1α, and low levels of the anti-inflammatory cytokine, IL-4; while the survival model showed low levels of TNF-α and IL-1α with high levels of IL-4. Conclusion: There were differences in the pathogenesis of the severe and survival models of malaria infection. These could be a basis for immunotherapy of malaria in the future. 

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CHIN, Voon Kin et al. COMPARISON OF PATHOGENESIS OF P. BERGHEI INFECTION IN MOUSE AND RAT MODELS. Journal of Health and Translational Medicine, [S.l.], v. 22, n. 2, p. 4-12, nov. 2019. ISSN 2289-392X. Available at: <https://jummec.um.edu.my/article/view/16835>. Date accessed: 06 july 2020. doi: https://doi.org/10.22452/jummec.vol22no2.2.
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