AUTOLOGOUS CHONDROCYTE IMPLANTATION FOR KNEE FOCAL CARTILAGE DEFECTS: 3 YEARS’ FOLLOW-UP AT THE UNIVERSITY MALAYA MEDICAL CENTRE

Abstract

Autologous chondrocyte implantation (ACI) is a widely accepted procedure for the treatment of large, full-thickness chondral defects involving various joints, but its use in developing countries is limited because of high cost and failure rates due to limited resources and support systems. Five patients (age <45 years) with focal cartilage defects received ACI at University of Malaya from 2006 to 2007 and followed up for 36 months. The average presubjective Knee Evaluation Forms (IKDC) improved from 38.44'6.29 to 25.6'8.04 postoperatively, the Oxford Knee Score (OKS) went from 25.6'8.04 to 13.96'1.63 and the American Knee Society Score (AKSS) improved from 80'14.33 to 92.96'5.82 post-operatively. Thus improvements were seen in the IKDC and AKSS score but not in the OKS. Magnetic resonance images showed the presence of cartilage tissue filling in the lateral and medial patellar facet and medial femoral condyle in three patients. Failures were seen in two patients, both with patellar defects and over the age of 36 years. Treatment with autologous chondrocyte implantation for focal cartilage defect in lateral and medial patellar facet and medial femoral condyle showed early improvement which was maintained at 3 yrs follow-up. ACI provided satisfactory outcome in focal cartilage defects involving the femoral condyle.