Manuka Honey as an Adjunct to Nonsurgical Periodontal Treatment: A Pilot Study

Authors

  • Syarida Hasnur Safii Department of Restorative Dentistry, Faculty of Dentistry, Universiti Malaya, Kuala Lumpur, Malaysia
  • Natalie J. Medlicott School of Pharmacy, University of Otago, Dunedin, New Zealand
  • Trudy J. Milne Sir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, New Zealand
  • Warwick J. Duncan Sir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, New Zealand

DOI:

https://doi.org/10.22452/adum.vol30.5

Keywords:

root surface debridement, antimicrobial, Porphyromonas gingivalis, polymerase chain reaction

Abstract

This pilot study evaluated the effect of manuka honey as a subgingival adjunct to scaling and root surface debridement in the treatment of periodontitis. This study used a split-mouth design with a 3-month follow-up in seven participants diagnosed with periodontitis Stage III Grade B or C. Root surface debridement was performed on one side of the mouth (control); the other side received debridement plus manuka honey application (test). Clinical parameters were recorded at baseline, 6- and 12-weeks. Gingival crevicular fluid and subgingival plaque were sampled. Microbiological outcomes were analysed using benzoylarginine p-nitroanilide assay and polymerase chain reaction assays. Single application of manuka honey to periodontal pockets did not result in additional reduction of pocket depth, improvement of attachment levels or changes in p-nitroaniline enzymes when compared with root surface debridement alone. However, test sites exhibited greater reduction in bleeding than control sites, mean differences 1.3 (95%CI 1.2-1.5) and 1.7 (95%CI 1.5-1.9) at 6-weeks and 12-weeks, respectively. The proportion of mutans streptococci decreased at 6-weeks in test sites but increased at 12-weeks in control sites. Adjunctive application of manuka honey to periodontal pockets improved gingival inflammation but did not demonstrate significant clinical benefits compared with root surface debridement alone.

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Published

2023-12-28

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Section

Original/Research Article